Carcinogenesis, Mutagenesis, Impairment of Fertility: No evidence of carcinogenic potential was observed during 2-year bioassay studies of xanax in rats at doses up to 30 mg/kg/day (150 times the maximum recommended daily human dose of 10 mg/day) and in mice at doses up to 10 mg/kg/day (50 times the maximum recommended daily human dose) . Many psychiatrists have now class=highlight>come to the general consensus that xanax poses a particularly high risk for abuse, misuse and dependence . Distinguishing between withdrawal emergent signs and symptoms and the recurrence of illness is often difficult in patients undergoing dose reduction. Some patients have experienced considerable difficulty in tapering and discontinuing from XANAX, especially those receiving higher doses for extended periods. It is most useful in the "classic" generational PNE with childhood onset; gastroesophageal reflux or irritable bowel syndrome, with panic attacks not phobic anxiety . In all three studies, XANAX was superior to placebo on a variable defined as "the number of patients with zero panic attacks" (range, 37- 83% met this criterion), as well as on a global . Anxiety associated with depression is responsive to Xanax . Benzodiazepine abuse is on the rise, according to the Health and Human Service's Drug Abuse Warning Network. Drugs demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving xanax (caution and consideration of appropriate

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